Chiral discrimination by phosphorescence

Coupling to chiral electrokinetic chromatography: Quenched phosphorescence detection of methotrexate

Switching between Phosphorescence and Fluorescence Controlled by Chiral Self‐Assembly

Helical self-assembly plays a unique role in regulating the localized excitations of π functional systems, which can also bring highly multi-scale orders, and show a special effect to tune the energy of electronics, vibration, and rotation of molecules. Due to controllable and dynamic property of chiral self-assembly, highly ordered and helical assemblies can be obtained to exhibit amplificatio...

Quenched phosphorescence as alternative detection mode in the chiral separation of methotrexate by electrokinetic chromatography

Quenched phosphorescence was used, for the first time, as detection mode in the chiral separation of methotrexate (MTX) enantiomers by electrokinetic chromatography. The detection is based on dynamic quenching of the strong emission of the phosphorophore 1-bromo-4-naphthalene sulfonic acid (BrNS) by MTX under deoxygenated conditions. The use of a background electrolyte with 3 mg/mL 2-hydroxypro...

Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα.

BACKGROUND Human topoisomerase IIα unlinks catenated chromosomes and preferentially relaxes positive supercoils. RESULTS Supercoil chirality, twist density, and tension determine topoisomerase IIα relaxation rate and processivity. CONCLUSION Strand passage rate is determined by the efficiency of transfer segment capture that is modulated by the topoisomerase C-terminal domains. SIGNIFICAN...

Chiral Discrimination in Solutions and in Langmuir Monolayers

In this paper we examine theoretically the chiral discrimination of molecules with a single chiral center. We propose a definition of the chiral discrimination parameter A in terms of the difference between the second virial coefficient of pure enantiomers and their racemic mixture. This parameter enters in the equation of state of racemic mixtures and will determine their phase diagrams. We ca...